Chapter 5 - HUMAN HEALTH EFFECTS AND TOXICOLOGY
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چکیده
All mercurial compounds are toxic and they affect many organ systems both during pre-natal and post-natal development and in adulthood. Mercury compounds are neurotoxic. Some are immunologically active. The main toxicity stems from the binding of mercury to sulfhydryl groups of enzymes and other proteins, thereby disrupting their structure and function. This interferes with basic cellular processes and damages or kills cells. The different forms of mercury differ in their ability to penetrate membranes and gain access to organs such as the brain. It is generally the neurotoxicity, that is of greatest importance, although some forms of mercury damage the kidneys and some compounds are highly corrosive to skin and mucous membranes.
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